Evaluation of some immunological and inflammatory indices in cigarette smokers of Basra province

Abstract

Objectives: The aim of the present study was to find out the effect of
cigarettes smoking on several haematological, immunological parameters
and inflammatory proteins C-reactive proteins (CRP) and complement (C3
and C4).
Methods: Whole blood and serum samples were taken from 32 healthy
smokers and 31 non-smokers male as control (19-40 years) in order to
detect the total WBCs and differential count, phagocytosis activity and
serum inflammatory proteins both of CRPs and complements (C3 and C4).
Results: The total number of WBCs and neutrophils were significantly
higher in smokers, but their phagocytic activity was significantly decreased.
In relation to inflammatory proteins, both of CRPs and complement
proteins (C3 and C4) were increased significantly higher in smokers. The
number of smokers has a significant increase in urban rather than rural area.
In addition, no significant differences were observed in the numbers of
lymphocytes (p= 0.118) and mass body index (MBI p= 0.367) between
smokers and non-smokers.
Conclusion: Cigarette smoking has severe adverse effects on different
immunologic parameters as it leads to increase in all of the total WBCs
count, neutrophils and lymphocytes as well as both of the inflammatory
proteins ( CRPs and complement (C3 and C4)). While on the other hand,
phagocytic activity was decreased.