Apo Lipoprotein A1 and High Density Lipoprotein As Risk Marker Among Myocardial Infarction Patients in General Hospital in Kerbala City
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Abstract
Objectives: All regions of the world has ability to cause presumed disease load from ischemic heart disease and can expect fundamental raise in together morbidity and mortality rates , it is expecting that jointly morbidity and mortality rates from ischemic heart disease will multiple through 1990 and 2020. This study was designed to estimate some biochemical marker, Apo lipoprotein A1, high density lipoprotein among patients with Acute myocardial infarction compared to healthy control. Methods: A case control study was conducted in Al-Husain general hospital in Karbala city, it included forty four cases with recent myocardial infarction and similarity number of age and sex matched healthy controls. The healthy controls group were chosen from medical staff and relatives with no sign and symptoms of coronary heart disease. Results: The study shows a highly significant decrease in the level of Apo lipoprotein A1 and high density lipoprotein cholesterol among acute myocardial infarction patients compared with healthy controls P. value(0.0001). Conclusion: The preserved association of ApoA1 with risk of AMI. As well as Low Apo A1 & HDL-cholesterol levels among MI cases compared with controls study was presenting.
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References
Barr D.P., Russ E.M. and Eder H.A. "Protein –lipid relationships in human plasma . II :In atherosclerosis and related condition". Am. J. Med. 1951;11(4):480-493. DOI: 10.1016/0002-9343(51)90183-0.
Murray C.J.L., Lopez A.D. "The global burden of disease: a comprehensive assessment of mortality and disability from disease, injuries and risk factors in 1990 and projected to 2020". Boston (MA): Harvard School of Health. 1996; p. 1-52.
Giampaolo N., Iacoviello L., Cianflone D. and Crea F. "Coronary risk factors: new perspectives". Int. J. Epidemiol. 2001; 30(1): 41-47. DOI:10.1093/ije/30.suppl_1.S41.
Cases
Controls
3
16
Mean APO A1…
Cases
Controls
91
45
Mean HDL…
Sci. J. Med. Res. Vol. 4, Issue 16, pp 134- 137 Autumn 2020 136
.
Pocock S.J., Shaper A.G. and Phillips A.N. "Concentrations of high density lipoprotein cholesterol, triglycerides, and total cholesterol in ischemic heart disease". BMJ. 1989; 298: 998–1002.
Castelli W.P., Garrison R.J., Wilson P.W., et al. "Incidence of coronary heart disease and lipoprotein cholesterol levels". The Framingham study. JAMA. 1986; 256(20): 2835–8.
Garfagnini A., Devoto G., Rosselli P., et al. "Relationship between HDL cholesterol and Apolipoprotein A1 and the severity of coronary artery disease". Eur. Heart J. 1995; 16(4): 465–70. DOI: 10.1093/oxfordjournals.eurheartj.a060937.
Sigurdsson G., Baldursdottir A., Sigvaldason H., et al. "Predictive value of Apolipoprotein in a prospective survey of coronary artery disease in men". Am. J. Cardiol. 1992; 69:1251–4. DOI: 10.1053/ejvs.2002.1678.
Graziani M.S., Zanolla L., Righetti G., Marchetti C., Mocarelli P. and Marcovina S.M. "Plasma Apolipoprotein A1 and B in survivors of myocardial infarction and in a control group". Clin. Chem. 1998; 44(1):134–140.
Hammed A. "Serum ApoA1, B and other lipid in men with coronary heart disease". Baghdad university PhD Thesis 1989; 114-140.
Zaid S., Mohamed H., Abdul Al-Hay M. and Nahi H. "Plasma lipid & Apo lipoproteins as discriminators for presence & severity of angiographically defined CAD". Circulation. 1983; 3(18): 1248-52.
Sharma R. and Sinph V. "Serum ApoA1 in the patients of MI in different age group". Indian J. of clinical Biochemistry. 2001; 16(1): 122-126. DOI: 10.1007/BF02867581.
Schmidt S.B., Waserman A.G., Musing R.A., Schitsman S.E. et al. "Lipoprotein and ApoA1 level in angiographically defined coronary atherosclerosis". Am. J. Cardiol. 1985; 55:1459-62.
Ahmed Kamel A. "Evaluation of plasma malon dieldehyde level among Iraqi patients with heart disease". Medical technology. Msc. thesis .2009; 75-79.
Al- Muhtaseb N., N. Hayat N. and Al- Khafaji M. "Lipoproteins and Apolipoprotiens in young male survivors of MI". Atherosclerosis. 1989; 77(2-3): 131-138. DOI: https://doi.org/10.1016/0021-9150(89)90074-9.
Al- Nozha M.M., Yaqauby M.R.A., Al-Maatong M.A., Nazeer B., Al- Kadra A.H. "Coronary artery disease in Saudia Arabia". Saudia Medical J. 2004; 25(9): 1165-1171.
Madithati A.R., Vanaja P.V. and Seshadri R. "Acute MI in South East India population compression of traditional and novel cardiovascular risk factors research". J. of Medicine and Medical sciences. 2009; 4(2): 202-209.
Pairsm P., Pugue J., Gerstein H., Zachariah E., Savitha D. and Yusuf S. "Risk factor of AMI in Indians". Lancet. 1996; 348(9024): 358-63. DOI: https://doi.org/10.1016/S0140-6736(96)02507-X
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