A Lycopene from Naganishia albidosimilis : A Promising Natural Antifungal against Echinococcus granulosus Use of lycopene as an effective antimicrobial against Echinococcus granulosus

Abstract

Background and Objective: Pathogenic parasites are among the microorganisms that pose a threat to humans, The natural compound lycopene was extracted from the yeast Naganishia albidosimilis to evaluate its antimicrobial activity against the pathogenic parasitic Echinococcus granulosus, which causes hydatid cysts in human. Methodology:E. granulosus was obtained from hydatid cyst samples collected during surgical procedures. After lycopene was extracted and purified, its purity was confirmed using several chemical and physical methods. Results: the extracted compound was pure lycopene .Experiments showed that lycopene possesses antimicrobial activity against E. granulosus. This effect was confirmed at the molecular level using polymerase chain reaction in real time (RT-PCR), E. granulosus expression of vital biological genes had significantly decreased.  Lycopene suppresses and development, as evidenced by the considerable decrease in expression of the Cox1 gene in E. granulosus. The Cox1 gene is crucial for cell cycle and division. Conclusion:  Lycopene is a promising  for the creation of efficient alternative natural remedies to fight these microbial pathogenicity  because of its antioxidant qualities and capacity to interfere with vital metabolic pathways