The Study The Association Between Betatrophin Level (Angiopoietin-Like Protein 8) And Insulin Resistance in Patients with Type 2 Diabetes

Abstract

Background: The exact relationship of betatrophin with insulin resistance remains controversial. Some studies report elevated betatrophin levels in insulin-resistant states, while others show inconsistent findings. Therefore, this study aims to investigate the association between betatrophin level and insulin resistance in T2DM patients, using marker homeostatic model assessment of insulin resistance (HOMA-IR); offering new insights into its potential as a biomarker for metabolic dysfunction or insulin resistance in T2DM. Methods: a case-control study and was conducted over a period of 12 months. A total of 100 participants were enrolled, including 50 patients with type 2 diabetes mellitus (T2DM) and 50 age and sex matched healthy controls. The diagnosis of patients with T2DM was established according to the American Diabetes Association (ADA) criteria. All parameters were estimations by standard methods. Results: Betatrophin levels were revealed significantly increase of betatropin, total cholesterol, triglyceride, low density lipoprotein, insulin and decrease high density lipoprotein in the T2DM patients group compared with the control group, (p = 0.001). Also, betatrophin showed 11600 area under the curve. Conclusion: Betatrophin levels was high in patients’ group, and this association is likely mediated through insulin resistance.