Lymphocyte Subsets Evaluation in Kidney Transplant Patients in Basrah Center for Kidney Diseases and Transplantation Lymphocyte Subsets Evaluation in Kidney Transplant Patients in Basrah Center for Kidney Diseases and Transplantation

Abstract

Kidney transplantation is the most common solid organ transplant and the most effective
treatment for end-stage kidney failure.
Methodology: Twenty-seven kidney transplant patients and sixteen healthy individuals
were evaluated using flow cytometry to count T,B,NK cells at the Basrah Centre for Kidney
Disease and Transplantation.
Results: Patients show higher mean CD3+/CD8+ cells count & lower mean CD4+/CD8+
cells count compared to control causing low CD4+/CD8+ratio, the difference is significant.
Further, patients have lower B cell and NK counts. These changes are partly attributed
to the effect of immunosuppression therapy received by Kidney transplant patients. In
addition to the possible effect of alternation in cytokine synthesis profile.
Conclusion: Due to changes in cytokine generation, immunosuppressors decreased T cell
activation and prevented the proliferation of activated B, T, and NK cells.