Use of Streptozotocin to Investigate the Effect of 6-paradol Nanoparticles on Sexual and Hormonal Markers in Diabetic rats Use of Streptozotocin to Investigate the Effect of 6-paradol Nanoparticles on Sexual and Hormonal Markers in Diabetic rats Sci.

Abstract

Objectives: The study aimed to explore the effect of 6-paradol nanoparticles in the therapy
of changes in body weight, testis, and epididymis in male rats caused by Streptozotocin.
Methods: : In diabetic rats, different concentrations of 6-paradol nanoparticles (20 mg and
40 mg/kg) were employed as a treatment for 60 days in several hormonal and histological
parameters. The criteria evaluated were body weight, testis and epididymis weight, and
the concentration of sex hormones (LH, FSH, and testosterone) in Rattus norvegicus
produced by Streptozotocin.
Results: The results showed a significant decrease in body weight and weight of testis
and epididymis, as well as a decrease in testosterone, LH, and FSH concentrations, and a
significant decrease in sperm concentration, motility, and viability, but an increase in the
percentage of abnormal sperms in the STZ (G3) group of rats, but a significant increase
in the weight of 6-paradol nanoparticle (G4&G5) group of rats.
Conclusion: : Because of its efficacy in treating the testis and epididymis, and because
it is also useful as an antibiotic or antioxidant, we can consider 6-paradol a very good
substance. It is very safe on the body and has a nanometer-sized size that allows it to enter
the cell and produce good results easily.