The Relationship Between Thymosin ?4 and Vitamin D3 in Systemic Lupus Erythmatosus Patients

Abstract

Objectives: The aim of the current study is to focus of the relationship between thymosin ?4 and vitamin D3 in systemic lupus erythmatosus patients. Methods: This study included sixty of systemic lupus erythematosus patients that diagnosed by clinic specialists by using (SLEDAI) taken from (Al-Hussein Medical City/Kerbala / IRAQ). During the period from January 2015 to December 2016. Control group of 30 healthy persons who matched in gender and age with patients, and haven't history for this disease. The majority of the SLE patients were female 95% , the ratio of female male 19:1. The age of SLE patients was ranging from (7-65) compared with healthy control group as a seem in age. Results: The result shows a significant decreasing in concentration of thymosin ?4, vitamin D3 and circulating complement factors (C3,C4) in active SLE patients compare with healthy control while significant increase in concentration of ANA and ds-DNA antibodies and disease activity measured using the SLE disease activity index (SLEDAI). Conclusion: Positive relationship between level thymosin ?4 and concentration vitamin D3. There is an inverse relationship between Thymosin ?4 and disease activity index of SLE.