Immunohistochemistry of Detection HER2 on Breast Cancer in Basra City

Abstract

Objectives: Breast cancer is the most typical style of cancer in females. The human epidermal growth factor receptor 2 (HER2) is a potential molecular target in breast carcinoma and it is abundantly expressed in this type of cancer and other cancers. The present study target is detection about HER2 in breast cancer patients of Basrah city. Methods: Fifty patients were registered and diagnosed as breast cancer disease patients and without breast cancer. Immunohistochemistry was carry out to evaluate the distribution of HER2 by using positive charge slide. Results: The result was screen about HER2 status in female patients with breast cancer in Basra city / Iraq, and the ages female patients with breast cancer ranged were from 20 to 60 years. The HER2 status reported there was no-significant difference in age groups of cancer status, while there was a significant association between stage I stage II and III of HER2 status and was (P= 0.001). Conclusion: This study review the role of HER2 diverse cancers, and diagnostic by immunohistochemistry assay. Immunohistochemistry is a well-established ancillary technique to facilitate the diagnosis of infectious and neoplastic processes and help to diagnosis and as a proof to appropriate therapy.