Improved Study of Itraconzole’s Effectiveness against Candida parapsilosis
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Abstract
Objective: The present study aims to improvement efficiency of antifungal agent Itraconazole by nanotechnology. Methods: Direct ion exchange between antibiotic itraconazole (ITZ) and zinc oxide layers (ZnO) was used to create a nanohybrid antibiotic ITZ-ZnO. FT-IR spectroscopy and X-Ray Diffraction were used to identify the novel nano antibiotic (XRD. The nanohybrid Itraconazole’s antifungal efficacy was investigated against Candida isolate from urinary tract infections, that diagnosed by Vitek. Results: The results showed that Fourier-transform infrared (FT-IR) spectroscopy results for the prepared antibiotics showed that the frequencies of some chemical groups shifted towards high and low frequencies. XRD revealed the presence of unique diffraction planes in the spectrum of the nanohybrid antibiotic when compared to the carrier spectrum Zinc oxide, which indicates that the prepared antibiotics under study is nanohybrid antibiotics. The diagnosis of yeast by Vitek was Candida parapsilosis. The results of the statistical analysis showed that the diameter of inhibition increases significantly (p ? 0.05) in the nanohyprid Itraconazole at a concentration of 100 ?g/mL compared with the free Itraconazole, dimeters of inhibition zone at 100 ?g/mL were (9.4 and 6.1) mm in nanoitraconazole and free Itraconazole, respectively. Conclusions: The success of loading itraconazole on zinc oxide as a carrier of the antibiotic. The activity of the nano-hybrid compound of itraconazole and zinc oxide gave a higher inhibition activity compared to free itraconazole.
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How to Cite
Al- Daamy, A. A. H., Qahtan, A. H., & Mohamed, R. A. (2021). Improved Study of Itraconzole’s Effectiveness against Candida parapsilosis. Scientific Journal of Medical Research, 5(20), 101–106. https://doi.org/10.37623/sjomr.v05i20.1
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Review Article