Effect of Bacterial Infection on Few Hormones in Urinary Tract Infections Patients

Abstract

Objective: The current study aims to isolate and diagnose the bacteria from urinary tract infection patients and study its relationship to few hormones such as Progesterone, Estrogen, Cortisol and FSH, in addition to Vitamin D.
Methods: Collection samples were carried out in Al-Housani hospital and Zain Al-Aabdin hospital during the period from December 2021 to March 2022. Forty-two patients had blood and urine samples taken, while 42 people who weren’t hospitalized served as the control group. The urine sample was centrifuged and examined microscopically to determine the urinary tract infection (UTI). Then the blood sample was cultured to obtain the bacteria and diagnose it with a VITEK device, hormones levels of progesterone,
estrogen, cortisol and follicle-stimulating hormone (FSH), in addition to vitamin D in the serum, were measured.
Results: UTI females were more than (76.19%) of males (23.18%). Twelve bacterial isolates were obtained from only female patients belonging to four bacteria genus, these bacteria: Enterococcus sp. (4 isolates), Staphylococcus saprophyticus (4 isolates), Klebsiella pneumonia ( 2 isolates), and E. coli (2 isolates). The concentration of vitamin D decreased in male and female patients (12.178 and 16.766) ng/mL, respectively, compared to the healthy controls. The presence of bacteria in female UTI patients led to an increase in the levels of both progesterone and estrogen (17.608 ng/mL and 1651.743 pg/mL), respectively. Also, the concentration of FSH in female UTI patients increased from its concentration in the healthy ones, which was (20.560 and 8.723) mIU/mL, respectively. The concentration of cortisol was not affected in patients.
Conclusions: Females are more infected with UTIs than males, and all bacterial species were isolated from females, Enterococcus sp. (4 isolates), Staphylococcus saprophyticus are the most common. Bacterial infection is related to a concentration of vitamin D in male and female patients, and have a relationship with a concentration of estrogen, progesterone and FSH in females.